Posted by: jeanne | June 2, 2009

cytokines cause depression

they’re intricately connected with the occurrence of depression.

here’s a research paper:

Cytokines, stress and depressive illness: brain-immune interactions
by
Anisman H, Merali Z.
Institute of Neurosciences,
Carleton University and Institute of Mental Health Research,
Royal Ottawa Hospital, University of Ottawa, Canada.
hanisman@ccs.Carleton.ca
Ann Med 2003;35(1):2-11

ABSTRACT

Cytokines, signaling molecules of the immune system, have been implicated as a contributing factor for mood disorders such as depression. Several lines of evidence supporting this contention are briefly reviewed and caveats are introduced. Essentially, a relationship between cytokines and depression is based on the findings that: 1) proinflammatory cytokines (interleukin-1, interleukin-6, tumor necrosis factor-alpha) and bacterial endotoxins elicit sickness behaviors (e.g., fatigue, soporific effects) and symptoms of anxiety/depression that may be attenuated by chronic antidepressant treatment, 2) cytokines induce neuroendocrine and central neurotransmitter changes reminiscent of those implicated in depression, and these effects are exacerbated by stressors, 3) severe depressive illness is accompanied by signs of immune activation and by elevations of cytokine production or levels, and 4) immunotherapy, using interleukin-2 or interferon-alpha, promotes depressive symptoms that are attenuated by antidepressant treatment. It is argued that cytokine synthesis and release, elicited upon activation of the inflammatory response system, provoke neuroendocrine and brain neurotransmitter changes that are interpreted by the brain as being stressors, and contribute to the development of depression. Furthermore, such effects are subject to a sensitization effect so that a history of stressful experiences or cytokine activation augment the response to later challenges and hence the evolution of depression.

so, inflammatory response is bad when it’s chronic. see here.

and why am i going on about this? (here’s more.)

well, they’re saying that cancer produces depression as a side effect.  and depression feeds cancer (i need to find a reference). so it’s like falling into a black  hole when you let depression take you. that’s why people die right after hitting retirement age when they don’t have anything to do.

they’re not saying that depression causes cancer. that’d be something i would say.

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Responses

  1. What a viscious fucking circle.

    Get cancer and be happy and then you may save yourself.

    xoxo

  2. xoxoxoxoxo

    Kisses and Hugs

    Love Renee xoxo


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