Posted by: jeanne | December 4, 2011

here’s where sugar is cancer’s achilles heel

anecdotal evidence says a diet full of sugar feeds cancer.  i haven’t researched that, so i’m uncertain, but here’s something that might work against it.

Cancer cells poisoned with sugar

04 December 2011IT’S a heavy price to pay for a sweet tooth. Researchers have tricked glucose-eating cancer cells into consuming a sugar that essentially poisons them – it leaves a “suicide” switch within the cells open to attack.

“Most cancer cells rely almost exclusively on glucose to fuel their growth,” says Guy Perkins of the University of California at San Diego. With Rudy Yamaguchi of Kyushu University in Fukuoka, Japan, Perkins found the cells would take up a similar sugar called 2-deoxyglucose. But this sugar physically dislodges a protein within the cell that guards a suicide switch. Once exposed, the switch can be activated by a drug called ABT-263. This kills the cell by liberating proteins that order it to commit suicide (Cancer Research, DOI: 10.1158/0008-5472.can-11-3091).

The approach could ultimately spell doom for several types of cancer, including liver, lung, breast and blood. In mice, the treatment made aggressive human prostate cancer tumours virtually disappear within days.

Yamaguchi and Perkins are now hoping to mount a clinical trial at UC San Diego.

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Responses

  1. I’m a cancer patient in the U.K. and wondered about participating in your clinical trial as I have a small amount of activity in my Liver after undergoing SIRT procedure in September, and two inactive nodules in my lungs. Last scanned in January

    • you’re mistaking me for a clinic. this is a blog by someone else with cancer. good luck to you.


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