Posted by: jeanne | March 6, 2012

an aspirin a day keeps the cancer away

well, here’s interesting news.  it’s good for cancer at a lower dose than you take for heart health.  now, where do you get nosh-aspirin?

Gas-filled aspirin is a potent anti-cancer drug

Updated 17:20 06 March 2012 by Andy Coghlan

Loading aspirin with gas dramatically boosts its cancer-fighting ability and might even blunt the harmful side effects of taking aspirin every day.

Aspirin has been shown to be effective in reducing the incidence of cancer: a trial last year showed that taking it daily for at least two years reduced the risk of colorectal cancer. Just 18 out of 427 people taking aspirin developed the cancer compared with 30 out of 434 on a placebo. But it can also cause ulcers and bleeding in the gut, which doesn’t necessarily make it a good option for healthy people.

The gut lining protects itself from damage by producing nitric oxide and hydrogen sulphide. So Khosrow Kashfi at The City College of New York developed NOSH-aspirin, which produces both gases as it breaks down.

Aspirin is known to damage cancer cells, which is thought to be behind its preventative effect. To test the new drug, Kashfi’s team added it to cells from 11 types of human tumour, including colon, pancreas, breast, lung and prostate cancer.

“It turned out to be significantly more potent than aspirin alone,” says Kashfi. With colon cancer, for example, NOSH-aspirin was 100,000 times more potent than the original drug, causing the cells to stop dividing, wither and die.

It is not yet clear what caused the increased potency but the results suggest that lower doses would be needed to fight cancer than for regular aspirin.

Further work by Kashfi showed that the new compound appears not to be harmful to animals (Biochemical and Biophysical Research Communications, in press). In mice with human colon cancer, daily doses for 18 days reduced tumour size by 85 per cent with no gut damage. “We could be looking at a human trial within two years,” he says.

“I welcome anything that promises to retain the health benefits of aspirin with fewer side effects,” says John Burn at Newcastle University in the UK. “But you have to be cautious whenever you consider giving people who are healthy something for a long time,” he says.

Journal reference: Medicinal Chemistry Letters, DOI: 10.1021/ml300002m

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  1. […] an aspirin a day keeps the cancer away (breastcancerblog.wordpress.com) […]


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